Today I want to talk about a peptide that has shown great promise for muscle wasting disease patients. I know your probably thinking WTF?? does that have to do with training and or dieting. Stick with me on this and I promise you'll be glad you did.
What is MK2866/Ostarine?
MK2866/Ostarine is the SARM that GTx is developing intended for the prevention and treatment for muscle wasting. It is at the moment undergoing clinical trials and could possibly be the medical prescription for prevention of cachexia, atrophy, and sarcopenia and for Hormone or Testoserone Replacement Therapy.
Being a research chemical, Ostarine belongs to a catergory of chemicals known as SARMs or selective androgen receptor modulators. SARMS create selective anabolic activity at certain androgen receptors and not others, hence their name. In comparison to testosterone and various other anabolic steroids and pro hormones, the advantage of SARMS such as (Ostarine) MK-2688 is that they do not have androgenic activity in non-skeletal-muscle tissues as do steroids and pro hormones.
Ostarine is effective in not only maintaining lean body mass (LBM) but in fact increasing it
It is typically described or named S1 on various interenet sources, but this is actually incorrect as S1 was a SARM that was develped quite some time ago and is no longer undergoing any further development.
How does MK2866/Ostarine work?
Selective androgen receptor modulators (SARMs) bind to the androgen receptor and demonstrate osteo (bone) and myo (muscular) anabolic activity.
Androgen receptor activation
Binding and activation involving Androgen receptors alters the expression of genes and increases protein synthesis, as a result, builds muscle.
So in essence, SARMS such as Ostarine causes muscle growth in the same manner as steroids, however unlike testosterone and other anabolic steroids and prohormones, SARMS (as nonsteroidal agents) DO NOT produce the growth effect on prostate and other secondary sexual organs.
Ostarine in particular exerts its anabolic effects on muscle tissue almost exclusively. So it doesn't just represent a new potential treatment option for a wide spectrum of conditions from muscle wasting diseases such as AIDS to cancer related conditions but it also has immense potential for muscle building for Bodybuilders, fitness, athletes and an agent to minimize atrophy during recovery periods from serious surgery or similar situations.
Advantages Of Ostarine when compared to Steroids/Prohormones
There is no need for pre cycle supports such as Hawthorn berry.
There is no need for on cycle supports such as milk thistle for the liver, policosanol or RYR for cholesterol etc.
Some suppression may be present at doses of 25mg+ run for longer than 4 weeks, however a stringent PCT of prescription SERMs like nolva or Clomid is not necessary.
High oral biovailabilty without significant damage to your liver as with oral steroids/Prohormones.
Great sense of well being while on, (without the aggression which can often detrimentally impact users daily lifes).
No need for a long time period off between cycles; the recommended time of period for normal cycles would be Time on +PCT, so for a typical 6 week cycle and 4 week PCT, a user would have to wait another 10 weeks after PCT to start another cycle.
Ostarine (MK-2866) also resulted in a dose-dependent decrease in LDL and HDL cholesterol levels, with the average LDL/HDL ratio for all doses remaining in the low cardiovascular risk category – hence there is little impact on cholesterol values.
Advantages Of Ostarine when compared to other SARMS
The metabolite M1 wich seems to cause toxicity in S4 (temporary occular disturbances) is not present in Ostarine.
Also unlike S4, Ostarine does not have androgenic properties in non muscle tissue.
Anabolic even at doses as low as 3mg
Great for strength
Great for lean mass gains
Great for body recomposition
Great for endurance (aerobic or anaerobic)
Joint healing abilities
Half life of circa 24 hours – only once a day dosing required.
So as you see if you stuck with me on this, on paper this seems to be the ultimate compound, especially for women athletes or for cutting up. Hell even bulking. So for those of you out there that are busting your ass in the gym and feel like your stuck and not making any progress and don't want to cross to the dark side, you may want to do some more research on this peptide. Or just be a guinea pig and try it out for 6 weeks. There's no experience like real experience. If you do try it out please come back and leave a comment. I would love to hear from people that are actually using it.
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